Fras1^tm1Chpk
Targeted Allele Detail

Summary

• Symbol: Fras1^tm1Chpk
• Name: Fraser extracellular matrix complex subunit 1; targeted mutation 1, George Chalepakis
• MGI ID: MGI:2667194
• Synonyms: Fras1-
• Gene: Fras1 Location: Chr5:96521814-96932587 bp, + strand Genetic Position: Chr5, 47.29 cM
• Alliance: Fras1^tm1Chpk page

Defective septation of right lung lobes in Fras1^tm1Chpk/Fras1^tm1Chpk embryos

Show the 2 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:83746
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: A lacZ/neo cassette was inserted into exon 6 of the gene. Immunofluorescence staining failed to detect protein in homozygous mutant mice. (J:83746)

Disease models

Expression

In Mice Carrying this Mutation:	50 assay results
In Structures Affected by this Mutation:	5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Fras1 Mutation: 217 strains or lines available

References

• Original: J:83746 Vrontou S, et al., Fras1 deficiency results in cryptophthalmos, renal agenesis and blebbed phenotype in mice. Nat Genet. 2003 Jun;34(2):209-14
• All: 5 reference(s)