Pdgfb^tm3.1Cbet
Targeted Allele Detail

Summary

• Symbol: Pdgfb^tm3.1Cbet
• Name: platelet derived growth factor, B polypeptide; targeted mutation 3.1, Christer Betsholtz
• MGI ID: MGI:2670574
• Synonyms: pdgf-b^ret, pdgfb^ret
• Gene: Pdgfb Location: Chr15:79880075-79899178 bp, - strand Genetic Position: Chr15, 37.85 cM, cytoband E
• Alliance: Pdgfb^tm3.1Cbet page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:84701
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: The floxed neo cassette was removed from intron 5 of Pdgfb^tm3Cbet via in vivo cre mediated recombination. The stop codon that was inserted into exon 6 remained intact and precluded the translation of the retention motif. (J:84701)

Expression

In Structures Affected by this Mutation:

16 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pdgfb Mutation: 15 strains or lines available

References

• Original: J:84701 Lindblom P, et al., Endothelial PDGF-B retention is required for proper investment of pericytes in the microvessel wall. Genes Dev. 2003 Aug 1;17(15):1835-40
• All: 24 reference(s)