Cd44^tm1.1Ugu
Targeted Allele Detail

Summary

• Symbol: Cd44^tm1.1Ugu
• Name: CD44 antigen; targeted mutation 1.1, Ursula Gunthert
• MGI ID: MGI:2679706
• Synonyms: CD44v6/v7-, CD44v6-v7 KO
• Gene: Cd44 Location: Chr2:102641486-102732010 bp, - strand Genetic Position: Chr2, 54.13 cM
• Alliance: Cd44^tm1.1Ugu page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:62867
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: This allele was generated from the ES cell line used to produce Cd44^tm1Ugu by transient cre expression in the ES cells prior to electroporation. In these mice, both exons v6 and v7 are removed or deficient. (J:62867)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 9 strains available Cell Lines: 0 lines available
• Carrying any Cd44 Mutation: 72 strains or lines available

References

• Original: J:62867 Wittig BM, et al., Abrogation of experimental colitis correlates with increased apoptosis in mice deficient for CD44 variant exon 7 (CD44v7). J Exp Med. 2000 Jun 19;191(12):2053-64
• All: 7 reference(s)