Vegfc^tm1Ali
Targeted Allele Detail

Summary

• Symbol: Vegfc^tm1Ali
• Name: vascular endothelial growth factor C; targeted mutation 1, Kari Alitalo
• MGI ID: MGI:3026650
• Synonyms: Vegfc^-, Vegfc^LacZ, Vegfc^lz
• Gene: Vegfc Location: Chr8:54530567-54639489 bp, + strand Genetic Position: Chr8, 29.2 cM, cytoband B3
• Alliance: Vegfc^tm1Ali page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:87394
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A portion of first coding exon, including the start codon and the coding region, was replaced with a lacZ and neo cassette inserted by homologous recombination. RT-PCR analysis of homozygous mutant embryos indicated that no normal transcript was produced from this loci. LacZ transcript was detected by RT-PCR analysis of mutant embryos. (J:87394)

Disease models

Expression

In Mice Carrying this Mutation:	45 assay results
In Structures Affected by this Mutation:	2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Vegfc Mutation: 28 strains or lines available

References

• Original: J:87394 Karkkainen MJ, et al., Vascular endothelial growth factor C is required for sprouting of the first lymphatic vessels from embryonic veins. Nat Immunol. 2004 Jan;5(1):74-80
• All: 21 reference(s)