Sema4d^tm1Kik
Targeted Allele Detail

Summary

• Symbol: Sema4d^tm1Kik
• Name: sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D; targeted mutation 1, Hitoshi Kikutani
• MGI ID: MGI:3027762
• Synonyms: CD100^-, Sema4D(-)
• Gene: Sema4d Location: Chr13:51839565-51947783 bp, - strand Genetic Position: Chr13, 26.16 cM, cytoband B1
• Alliance: Sema4d^tm1Kik page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:66033
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The putative exon 1 which contains the initiation codon was replaced with a neomycin resistance cassette. Absence of expression was established by immunological staining of spleen cells. (J:66033)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Sema4d Mutation: 88 strains or lines available

References

• Original: J:66033 Shi W, et al., The class IV semaphorin CD100 plays nonredundant roles in the immune system. Defective B and T cell activation in CD100-deficient mice. Immunity. 2000 Nov;13(5):633-42
• All: 22 reference(s)