Ripk3^tm1Vmd
Targeted Allele Detail

Summary

• Symbol: Ripk3^tm1Vmd
• Name: receptor-interacting serine-threonine kinase 3; targeted mutation 1, Vishva M Dixit
• MGI ID: MGI:3028853
• Synonyms: rip3^-
• Gene: Ripk3 Location: Chr14:56022452-56026314 bp, - strand Genetic Position: Chr14, 28.19 cM, cytoband C1
• Alliance: Ripk3^tm1Vmd page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:87683
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A sequence fragment encompassing exons 1 through 3 was replaced with a loxP site flanked neomycin resistance gene cassette. Protein was undetected by Western blot analysis of homozygous mutant MEFs, bone marrow-derived macrophages, B and T lymphocytes, and thymocytes. (J:87683)

Expression

In Mice Carrying this Mutation:

31 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ripk3 Mutation: 34 strains or lines available

References

• Original: J:87683 Newton K, et al., Kinase RIP3 is dispensable for normal NF-kappa Bs, signaling by the B-cell and T-cell receptors, tumor necrosis factor receptor 1, and Toll-like receptors 2 and 4. Mol Cell Biol. 2004 Feb;24(4):1464-9
• All: 247 reference(s)