Ticam1^tm1Aki
Targeted Allele Detail

Summary

• Symbol: Ticam1^tm1Aki
• Name: TIR domain containing adaptor molecule 1; targeted mutation 1, Shizuo Akira
• MGI ID: MGI:3029019
• Synonyms: Ticam1-, TRIF^-
• Gene: Ticam1 Location: Chr17:56576462-56583767 bp, - strand Genetic Position: Chr17, 29.24 cM
• Alliance: Ticam1^tm1Aki page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:84679
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The entire exon of this single-exon locus was replaced with a neomycin resistance gene cassette inserted by homologous recombination. (J:84679)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ticam1 Mutation: 54 strains or lines available

References

• Original: J:84679 Yamamoto M, et al., Role of adaptor TRIF in the MyD88-independent toll-like receptor signaling pathway. Science. 2003 Aug 1;301(5633):640-3
• All: 286 reference(s)