Il1rn^tm1Nick
Targeted Allele Detail

Summary

• Symbol: Il1rn^tm1Nick
• Name: interleukin 1 receptor antagonist; targeted mutation 1, Martin J H Nicklin
• MGI ID: MGI:3038876
• Synonyms: Il1rn^-
• Gene: Il1rn Location: Chr2:24226872-24241503 bp, + strand Genetic Position: Chr2, 16.36 cM
• Alliance: Il1rn^tm1Nick page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:59410
• Parent Cell Line: E14TG2a (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: Homologous recombination was used to fuse a vector containing the aph gene driven by a beta actin promoter with the ORF at exon 3, which encodes the single folding domain. This is codon 77 in the secreted form of the endogenous protein or codon 82 of the intact cell form. RT-PCR revealed that no transcript was found in mutant peritoneal macrophages. (J:59410)

Expression

In Structures Affected by this Mutation:

6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 5 strains available Cell Lines: 0 lines available
• Carrying any Il1rn Mutation: 23 strains or lines available

References

• Original: J:59410 Nicklin MJ, et al., Arterial inflammation in mice lacking the interleukin 1 receptor antagonist gene. J Exp Med. 2000 Jan 17;191(2):303-12
• All: 12 reference(s)