Ticam2^tm1Aki
Targeted Allele Detail

Summary

• Symbol: Ticam2^tm1Aki
• Name: TIR domain containing adaptor molecule 2; targeted mutation 1, Shizuo Akira
• MGI ID: MGI:3040182
• Synonyms: Ticam2-, Tram^_, TRAM^-
• Gene: Ticam2 Location: Chr18:46691298-46707600 bp, - strand Genetic Position: Chr18, 24.65 cM
• Alliance: Ticam2^tm1Aki page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:86256
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A 1.0 kb fragment encompassing the entire coding region of this single-exon gene was replaced with a neomycin selection cassette. Protein was undetected by Western blot analysis of immunoprecipitated lysates from homozygous mutant macrophages. (J:86256)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ticam2 Mutation: 25 strains or lines available

References

• Original: J:86256 Yamamoto M, et al., TRAM is specifically involved in the Toll-like receptor 4-mediated MyD88-independent signaling pathway. Nat Immunol. 2003 Nov;4(11):1144-50
• All: 24 reference(s)