Tg(SFTPC-TAg)5.1Jaw
Transgene Detail

Summary

• Symbol: Tg(SFTPC-TAg)5.1Jaw
• Name: transgene insertion 5.1, Jeffrey A Whitsett
• MGI ID: MGI:3040278
• Synonyms: SP-C/TAg, Tg(SFTPC-TAg)5Jaw
• Transgene: Tg(SFTPC-TAg)5.1Jaw Location: unknown
• Alliance: Tg(SFTPC-TAg)5.1Jaw page

Transgene origin

• Strain of Origin: FVB/N

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Mutation details: This transgene contains the human SFTPC (pulmonary-associated surfactant protein C) promoter and the wild-type alleles of the SV40 Tag and tag (large and small T) antigen genes. (J:70783)

Tumor Data

List all tumor models in MMHCdb carrying Tg(SFTPC-TAg)5.1Jaw

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

Notes

Transgene also called: SP-C-TAg.

This line was derived from one of three transgenic founder mice. Founder 2, a female, had two litters of which all the pups died within a day of birth. Founder 5.2, a male, sired 48 progeny, none of which carried the transgene. Only Founder 5.1, whose sex was not stated, generated viable transgenic offspring.

References

• Original: J:70783 Wikenheiser KA, et al., Simian virus 40 large T antigen directed by transcriptional elements of the human surfactant protein C gene produces pulmonary adenocarcinomas in transgenic mice. Cancer Res. 1992 Oct 1;52(19):5342-52
• All: 3 reference(s)