Nrxn2^tm1Sud
Targeted Allele Detail

Summary

• Symbol: Nrxn2^tm1Sud
• Name: neurexin II; targeted mutation 1, Thomas C Sudhof
• MGI ID: MGI:3042719
• Gene: Nrxn2 Location: Chr19:6468786-6583247 bp, + strand Genetic Position: Chr19, 4.65 cM
• Alliance: Nrxn2^tm1Sud page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:89452
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neo cassette replaced the first exon, which contains the complete 5' UTR, start codon, signal peptide and the first LNS domain. Immunoblotting of mutant brain confirmed lack of protein expression. This knock-out affects the alpha isoform specifically. The beta isoform, transcribed from a downstream promoter, is not affected.. (J:89452)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 3 strains available Cell Lines: 0 lines available
• Carrying any Nrxn2 Mutation: 91 strains or lines available

References

• Original: J:89452 Missler M, et al., Alpha-neurexins couple Ca2+ channels to synaptic vesicle exocytosis. Nature. 2003 Jun 26;423(6943):939-48
• All: 13 reference(s)