Tfap2a^Mhdador
Chemically induced Allele Detail

Summary

• Symbol: Tfap2a^Mhdador
• Name: transcription factor AP-2, alpha; Martin Hrabe de Angelis doarad
• MGI ID: MGI:3045427
• Synonyms: DEA5, Doarad, Dor, Tfap2a^Dor
• Gene: Tfap2a Location: Chr13:40868778-40891852 bp, - strand Genetic Position: Chr13, 20.01 cM, cytoband A5-B1
• Alliance: Tfap2a^Mhdador page

Ocular phenotype of the Tfap2a^Mhdador/Tfap2a^Mhdador mouse

Show the 2 phenotype image(s) involving this allele.

Mutation origin

• Strain of Origin: C3HeB/FeJ

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• Mutation details: This allele has a C to T missense mutation at position 246 in the PY motif of its transactivation domain, resulting in a proline to leucine substitution at amino acid position 59. (J:90701)
• Inheritance: Dominant

Expression

In Structures Affected by this Mutation:

8 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Tfap2a Mutation: 39 strains or lines available

References

• Original: J:90701 Ahituv N, et al., An ENU-induced mutation in AP-2alpha leads to middle ear and ocular defects in Doarad mice. Mamm Genome. 2004 Jun;15(6):424-32
• All: 2 reference(s)