Tlr7^tm1Aki
Targeted Allele Detail

Summary

• Symbol: Tlr7^tm1Aki
• Name: toll-like receptor 7; targeted mutation 1, Shizuo Akira
• MGI ID: MGI:3045662
• Synonyms: Tlr7^-
• Gene: Tlr7 Location: ChrX:166087925-166113554 bp, - strand Genetic Position: ChrX, 78.31 cM, cytoband F5
• Alliance: Tlr7^tm1Aki page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:90979
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neo replaced 1.8 kb of sequence that encodes a part of a leucine-rich repeat by homologous recombination. Recombination was confirmed by Southern analysis of tails from mutant males. (J:90979)

Expression

In Mice Carrying this Mutation:

2 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 3 strains available Cell Lines: 0 lines available
• Carrying any Tlr7 Mutation: 20 strains or lines available

References

• Original: J:90979 Hemmi H, et al., Small anti-viral compounds activate immune cells via the TLR7 MyD88-dependent signaling pathway. Nat Immunol. 2002 Feb;3(2):196-200
• All: 173 reference(s)