Fmn1tm1Zllr
Targeted Allele Detail
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Symbol: |
Fmn1tm1Zllr |
Name: |
formin 1; targeted mutation1, Rolf Zeller |
MGI ID: |
MGI:3046836 |
Synonyms: |
Fmndelta10 |
Gene: |
Fmn1 Location: Chr2:113158081-113547112 bp, + strand Genetic Position: Chr2, 57.3 cM, cytoband C1-qter
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Alliance: |
Fmn1tm1Zllr page
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Allele Type: |
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Targeted (Null/knockout) |
Mutations: |
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Insertion, Intragenic deletion
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Mutation details: Exon 10 was completely replaced with a PGK promoter and neomycin resistance gene cassette and a loxP site was inserted further downstream in intron 10. A correctly targeted ES cell line was further modified by the insertion of a loxP site flanked PGK promoter and hygromycin resistance gene cassette and an En-2 splice acceptor-IRES-LacZ expression cassette into exon 24. Removal of exon 10 causes a frame shift mutation, which disrupts the highly conserved formin homology domain SH2 and results in a protein product that includes out-of-frame translation after exon 9.
(J:91385)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Fmn1 Mutation: |
76 strains or lines available
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Original: |
J:91385 Zuniga A, et al., Mouse limb deformity mutations disrupt a global control region within the large regulatory landscape required for Gremlin expression. Genes Dev. 2004 Jul 1;18(13):1553-64 |
All: |
1 reference(s) |
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