Nlrc4^tm1Vmd
Targeted Allele Detail

Summary

• Symbol: Nlrc4^tm1Vmd
• Name: NLR family, CARD domain containing 4; targeted mutation 1, Vishva M Dixit
• MGI ID: MGI:3046934
• Synonyms: Ipaf^-, N4KO, NLRC4^-
• Gene: Nlrc4 Location: Chr17:74733254-74766140 bp, - strand Genetic Position: Chr17, 45.64 cM
• Alliance: Nlrc4^tm1Vmd page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:91292
• Parent Cell Line: C2 (Nagy) (ES Cell)
• Strain of Origin: C57BL/6NTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The sequence encoding amino acids 8-374 was replaced with a PGK-neo cassette. Western blot indicated absence of transcript in mutant macrophages. (J:91292)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Nlrc4 Mutation: 69 strains or lines available

References

• Original: J:91292 Mariathasan S, et al., Differential activation of the inflammasome by caspase-1 adaptors ASC and Ipaf. Nature. 2004 Jul 8;430(6996):213-8
• All: 113 reference(s)