Tg(CAG-OVAL)916Jen
Transgene Detail

Summary

• Symbol: Tg(CAG-OVAL)916Jen
• Name: transgene insertion 916, Marc K Jenkins
• MGI ID: MGI:3050829
• Synonyms: Actin-mOVA, actin-OVA, Act-mOVA, ActmOVA, actOVA, Tg(ACTB-OVA)916Jen, Tg(CAG-OVA)916Jen
• Transgene: Tg(CAG-OVAL)916Jen Location: unknown
• Alliance: Tg(CAG-OVAL)916Jen page

Transgene origin

• Strain of Origin: C57BL/6

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(CAG-OVAL)916Jen expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  chicken	OVAL (396058)

• Tg(CAG-OVAL)916Jen expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  chicken	CAG

• Mutation details: The transgene consists of a full-length chicken ovalbumin cDNA preceded by the 5' leader sequence of the mouse H2-K^b gene and followed by the DNA sequence encoding the short extracellular spacer and transmembrane domain of the mouse H2-D^b gene joined to the rabbit beta-globin polyadenylation signal; its expression is driven by the chicken beta-actin promoter under control of the CMV immediate early enhancer. Ovalbumin expression was detected immunohistochemically on the surfaces of cells of all organs and shown to function in skin-graft experiments as a minor histocompatibility antigen that triggered graft rejection by a mechanism involving both CD4 and CD8 T lymphocytes. (J:91742)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:91742 Ehst BD, et al., Development of a novel transgenic mouse for the study of interactions between CD4 and CD8 T cells during graft rejection. Am J Transplant. 2003 Nov;3(11):1355-62
• All: 68 reference(s)