Tg(Neurog3-cre)C1Able
Transgene Detail

Summary

• Symbol: Tg(Neurog3-cre)C1Able
• Name: transgene insertion C1, Andrew B Leiter
• MGI ID: MGI:3052639
• Synonyms: Neurgo3^TgBAC-Cre, Neurog3(cre), Neurog3Cre, ngn3-Cre, Tg(Neurog3-cre)#Able
• Transgene: Tg(Neurog3-cre)C1Able Location: unknown
• Alliance: Tg(Neurog3-cre)C1Able page

Transgene origin

• Strain of Origin: Not Specified

Transgene description

• Transgene Type: Transgenic (Recombinase)
• Mutation: Insertion
• Tg(Neurog3-cre)C1Able expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Neurog3 (MGI:893591)

• Mutation details: The Cre recombinase coding sequence, flanked by a nuclear localization signal and an SV40 polyadenylation site, was inserted just after the translation start site of the neurogenin 3 gene present in mouse BAC RP23-121F10, which also includes approximately 81 kb of 5' and 102 kb of 3' flanking DNA. Immunohistochemical analysis shows the same expression pattern for cre as for neurogenin 3 in adult and embryonic mice bearing this transgene. Cre recombinase activity is seen in cell types of pancreas, stomach, small intestine and colon that express or are descended from cells that express neurogenin 3 during development. (J:92204)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Neurog3 (mouse) Summary of all recombinase alleles driven by Neurog3. Comparative matrix view of recombinase activities Alliance mouse Neurog3 gene page

Expression

In Mice Carrying this Mutation:

16 assay results 7 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available

Notes

This is one of two independent lines demonstrating identical expression patterns.

References

• Original: J:92204 Schonhoff SE, et al., Neurogenin 3-expressing progenitor cells in the gastrointestinal tract differentiate into both endocrine and non-endocrine cell types. Dev Biol. 2004 Jun 15;270(2):443-54
• All: 92 reference(s)