Ceacam1^tm2Bcn
Targeted Allele Detail

Summary

• Symbol: Ceacam1^tm2Bcn
• Name: CEA cell adhesion molecule 1; targeted mutation 2, Nicole Beauchemin
• MGI ID: MGI:3053071
• Synonyms: 11H11, 2D2, Cc1^-, Ceacam1a-
• Gene: Ceacam1 Location: Chr7:25161132-25177028 bp, - strand Genetic Position: Chr7, 13.84 cM
• Alliance: Ceacam1^tm2Bcn page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:92376
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance cassette replaced the first two exons of the gene. These exons contain the ATG and encode the first Ig-like domain. RT-PCR confirmed absence of transcript in mutants. Western blot analysis on colon and liver did not detect protein. Northern blot analysis on colon and liver did not detect transcript. (J:92376, J:115838)

Expression

In Mice Carrying this Mutation:	3 assay results
In Structures Affected by this Mutation:	1 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Ceacam1^tm2Bcn

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ceacam1 Mutation: 45 strains or lines available

References

• Original: J:92376 Hemmila E, et al., Ceacam1a-/- mice are completely resistant to infection by murine coronavirus mouse hepatitis virus a59. J Virol. 2004 Sep;78(18):10156-65
• All: 37 reference(s)