Fcgrt^tm1Dcr
Targeted Allele Detail

Summary

• Symbol: Fcgrt^tm1Dcr
• Name: Fc fragment of IgG receptor and transporter; targeted mutation 1, Derry C Roopenian
• MGI ID: MGI:3511510
• Synonyms: FcRn^-
• Gene: Fcgrt Location: Chr7:44742417-44753246 bp, - strand Genetic Position: Chr7, 29.12 cM
• Alliance: Fcgrt^tm1Dcr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:94189
• Parent Cell Line: RW-4 (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Sequence from exon 1 and part of exon2 was replaced with a PGK-neo cassette. Quantitative PCR of liver cDNA indicated the absence of mRNA. Western blot analysis of neonatal intestinal extracts failed to reveal protein product. (J:94189)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 23 strains available Cell Lines: 0 lines available
• Carrying any Fcgrt Mutation: 61 strains or lines available

References

• Original: J:94189 Roopenian DC, et al., The MHC class I-like IgG receptor controls perinatal IgG transport, IgG homeostasis, and fate of IgG-Fc-coupled drugs. J Immunol. 2003 Apr 1;170(7):3528-33
• All: 86 reference(s)