Tg(Alb1-HCVN)35Sml
Transgene Detail

Summary

• Symbol: Tg(Alb1-HCVN)35Sml
• Name: transgene insertion 35, Stanley M Lemon
• MGI ID: MGI:3513779
• Synonyms: FL-N/35
• Transgene: Tg(Alb1-HCVN)35Sml Location: unknown
• Alliance: Tg(Alb1-HCVN)35Sml page

Transgene origin

• Strain of Origin: (C3H/HeH x C57BL/6)F2

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Mutation details: A cDNA encoding the full open reading frame of a Japanese genotype 1b virus, HCV-N was cloned downstream of the promoter-enhancer sequences from the murine Albumin gene. The polyA sequence downstream of the insert was derived from the SV40 virus. The transgene was predicted to encode 10 distinct viral proteins. This allele record was associated with founder FL-N/35, which was the only founder line bred to any significant numbers. Transgene expression was detected in the liver. (J:63590)

Tumor Data

List all tumor models in MMHCdb carrying Tg(Alb1-HCVN)35Sml

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 3 strains available Cell Lines: 0 lines available

References

• Original: J:63590 Lemon SM, et al., A transgenic mouse model of steatosis and hepatocellular carcinoma associated with chronic hepatitis C virus infection in humans. Trans Am Clin Climatol Assoc. 2000;111:146-56; discussion 156-7
• All: 15 reference(s)