Pax6^Mhdaaey18
Chemically induced Allele Detail

Summary

• Symbol: Pax6^Mhdaaey18
• Name: paired box 6; Martin Hrabe de Angelis abnormal eyes 18
• MGI ID: MGI:3521718
• Synonyms: Aey18, Pax6^Aey18
• Gene: Pax6 Location: Chr2:105499245-105527709 bp, + strand Genetic Position: Chr2, 55.31 cM
• Alliance: Pax6^Mhdaaey18 page

Mutation origin

• Strain of Origin: C3HeB/FeJ

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• Mutation details: A G to A transition in the last base of intron 5 led to a splice defect, skipping exons 5a and 6, which comprise a large part of the paired domain, while leaving the homeo- and transactivation domains intact. (J:103785)

Expression

In Mice Carrying this Mutation:	9 assay results
In Structures Affected by this Mutation:	5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Pax6 Mutation: 94 strains or lines available

References

• Original: J:94457 Haubst N, et al., Molecular dissection of Pax6 function: the specific roles of the paired domain and homeodomain in brain development. Development. 2004 Dec;131(24):6131-40
• All: 3 reference(s)