Onecut1^tm1.1Mga
Targeted Allele Detail

Summary

• Symbol: Onecut1^tm1.1Mga
• Name: one cut domain, family member 1; targeted mutation 1.1, Maureen A Gannon
• MGI ID: MGI:3526029
• Synonyms: HNF6^flox, Oc1^flox
• Gene: Onecut1 Location: Chr9:74769203-74796930 bp, + strand Genetic Position: Chr9, 41.93 cM
• Alliance: Onecut1^tm1.1Mga page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:155058
• Parent Cell Line: TL1/TL-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of the coding region and an FRT site flanked neo cassette with a 3' loxP site was inserted downstream of the coding region. Germ-line flp-mediated recombination removed the neo cassette, leaving the coding region floxed. (J:155058)

Expression

In Mice Carrying this Mutation:	65 assay results 2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	9 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Onecut1 Mutation: 12 strains or lines available

References

• Original: J:155058 Zhang H, et al., Multiple, temporal-specific roles for HNF6 in pancreatic endocrine and ductal differentiation. Mech Dev. 2009 Dec;126(11-12):958-73
• All: 17 reference(s)