Summary |
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Transgene origin |
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Transgene description |
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Find Mice (IMSR) |
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Notes |
Six transgenic lines were generated from the A53T construct. The transgene is expressed within nigrostriatal dopaminergic neurons. A similar and consistent pattern of transgene expression in all lines of transgenic mice was revealed by in situ hybridization studies. Transgenic protein accumulation impacted neither the number of nigral neurons, nor the levels of striatal dopamine in animals up to one year of age. No overt nuerodegerative changes were detected in transgenic mice.
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References |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 09/17/2024 MGI 6.24 |
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