Gnb1l^{Gt(OST35527)Lex}
Gene trapped Allele Detail

Summary

• Symbol: Gnb1l^{Gt(OST35527)Lex}
• Name: guanine nucleotide binding protein (G protein), beta polypeptide 1-like; gene trap OST35527, Lexicon Genetics
• MGI ID: MGI:3530640
• Synonyms: Gnb1l^-, Gnb1l^{Gt(Betageo)520Lex}, LEXKO-443
• Gene: Gnb1l Location: Chr16:18317463-18385429 bp, + strand Genetic Position: Chr16, 11.46 cM
• Alliance: Gnb1l^{Gt(OST35527)Lex} page

Mutation origin

• Mutant Cell Line: OST35527
• Germline Transmission: Earliest citation of germline transmission: J:110101
• Parent Cell Line: Lex-1 (ES Cell)
• Strain of Origin: 129S5/SvEvBrd
• Project Collection: Lexicon

Mutation description

• Allele Type: Gene trapped (Null/knockout, Reporter)
• Mutation: Insertion of gene trap vector
• Mutation details: A gene-trapping cassette inserted into intron 2, 476 base pairs upstream of exon 3, which is the first coding exon. The insertion results in aberrant splicing to the beta-galactosidase gene and loss of downstream mRNA.
• Sequence Tags: Sequence tag details (1 tag)

  Tag ID	GenBank ID	Method	Tag Location (trapped strand)*	Select
  OST35527	CG495873 ; (MGI Seq Detail)	3' RACE	Chr16:18359184-18364908 bp (+)
  * GRCm39; (strand of gene trap mutagenesis)

• Genome Context: Genome Browser view of this mutation;

  10 gene trap insertions have trapped this gene; View all gene trap sequence tags in this region

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Gnb1l Mutation: 15 strains or lines available

References

• Original: J:110101 Paylor R, et al., Tbx1 haploinsufficiency is linked to behavioral disorders in mice and humans: implications for 22q11 deletion syndrome. Proc Natl Acad Sci U S A. 2006 May 16;103(20):7729-34
• All: 4 reference(s)