Ralbp1^{Gt(OST359995)Lex}
Gene trapped Allele Detail

Summary

• Symbol: Ralbp1^{Gt(OST359995)Lex}
• Name: ralA binding protein 1; gene trap OST359995, Lexicon Genetics
• MGI ID: MGI:3530809
• Synonyms: Ralbp1^{Gt(IRESBetageo)562Lex}, RLIP76^-
• Gene: Ralbp1 Location: Chr17:66155410-66192750 bp, - strand Genetic Position: Chr17, 35.26 cM
• Alliance: Ralbp1^{Gt(OST359995)Lex} page

Mutation origin

• Mutant Cell Line: OST359995
• Germline Transmission: Earliest citation of germline transmission: J:100087
• Parent Cell Line: Lex-1 (ES Cell)
• Strain of Origin: 129S5/SvEvBrd
• Project Collection: Lexicon

Mutation description

• Allele Type: Gene trapped (Null/knockout, Reporter)
• Mutation: Insertion of gene trap vector
• Mutation details: The gene trap vector VICTR37 incorporated into the 5' region of the locus, just upstream of the first coding exon(NM_009067.1). RT-PCR analysis revealed that the transcript was absent in the homozygous mutant mice. Western blot of mutant tissues demonstrated the absence of protein. (J:82809, J:100087)
• Sequence Tags: Sequence tag details (1 tag)

  Tag ID	GenBank ID	Method	Tag Location (trapped strand)*	Select
  OST359995	CG636036 ; (MGI Seq Detail)	3' RACE	Chr17:66171483-66174826 bp (-)
  * GRCm39; (strand of gene trap mutagenesis)

• Genome Context: Genome Browser view of this mutation;

  140 gene trap insertions have trapped this gene; View all gene trap sequence tags in this region

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Ralbp1 Mutation: 82 strains or lines available

References

• Original: J:100087 Awasthi S, et al., RLIP76 is a major determinant of radiation sensitivity. Cancer Res. 2005 Jul 15;65(14):6022-8
• All: 9 reference(s)