Ralgds^tm1Cjm
Targeted Allele Detail

Summary

• Symbol: Ralgds^tm1Cjm
• Name: ral guanine nucleotide dissociation stimulator; targeted mutation 1, Christopher J Marshall
• MGI ID: MGI:3574574
• Synonyms: RalGDS^-, RalGDSⁿ
• Gene: Ralgds Location: Chr2:28403137-28443093 bp, + strand Genetic Position: Chr2, 19.38 cM, cytoband A3
• Alliance: Ralgds^tm1Cjm page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:96936
• Parent Cell Line: RW-4 (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 9-15, which make up part of the catalytic domain, were removed via cre-mediated recombination. Northern blot of mutant MEFs confirmed the lack of transcript. (J:96936)

Tumor Data

List all tumor models in MMHCdb carrying Ralgds^tm1Cjm

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Ralgds Mutation: 52 strains or lines available

References

• Original: J:96936 Gonzalez-Garcia A, et al., RalGDS is required for tumor formation in a model of skin carcinogenesis. Cancer Cell. 2005 Mar;7(3):219-26
• All: 2 reference(s)