Foxp3^tm2Ayr
Targeted Allele Detail

Summary

• Symbol: Foxp3^tm2Ayr
• Name: forkhead box P3; targeted mutation 2, Alexander Y Rudensky
• MGI ID: MGI:3574964
• Synonyms: Foxp3^eGFP, Foxp3^gfp, Foxp3-GFP, Foxp3-GFP.KI, FoxP3-GFP-KI
• Gene: Foxp3 Location: ChrX:7445915-7461482 bp, + strand Genetic Position: ChrX, 3.41 cM
• Alliance: Foxp3^tm2Ayr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:97029
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (No functional change, Reporter)
• Mutation: Insertion
• Mutation details: The complete EGFP coding sequence was inserted in-frame in the first coding exon while an FRT site flanked neomycin resistance gene cassette and a loxP site were inserted 246 bp 5' of exon 1. Chimeric male mice were subsequently mated to a Flp-deleter strain to excise the neo cassette. Gene function was not affected by this mutation. (J:97029)

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 6 strains available Cell Lines: 0 lines available
• Carrying any Foxp3 Mutation: 58 strains or lines available

References

• Original: J:97029 Fontenot JD, et al., Regulatory T cell lineage specification by the forkhead transcription factor foxp3. Immunity. 2005 Mar;22(3):329-41
• All: 215 reference(s)