Park7^tm1Dsp
Targeted Allele Detail

Summary

• Symbol: Park7^tm1Dsp
• Name: Parkinson disease (autosomal recessive, early onset) 7; targeted mutation 1, David S Park
• MGI ID: MGI:3576227
• Synonyms: DJ-1^-, Park7^tm1Mak
• Gene: Park7 Location: Chr4:150981590-150994378 bp, - strand Genetic Position: Chr4, 81.52 cM, cytoband E1
• Alliance: Park7^tm1Dsp page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:97366
• Parent Cell Line: E14K (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion, Nucleotide substitutions
• Mutation details: Exons 3-5 were replaced with a neomycin resistance gene. Exon 1 was modified to contain a premature stop codon, resulting in a transcript containing only the first 8 amino acids. Absence of transcript was confirmed by Northern blot of RNA from mutant MEFs. Absence of protein was shown by Western blot of mutant cortical neurons. (J:97366)

Disease models

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Park7 Mutation: 56 strains or lines available

References

• Original: J:97366 Kim RH, et al., Hypersensitivity of DJ-1-deficient mice to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyrindine (MPTP) and oxidative stress. Proc Natl Acad Sci U S A. 2005 Apr 5;102(14):5215-20
• All: 15 reference(s)