Irf7^tm1Ttg
Targeted Allele Detail

Summary

• Symbol: Irf7^tm1Ttg
• Name: interferon regulatory factor 7; targeted mutation 1, Tadatsugu Taniguchi
• MGI ID: MGI:3577089
• Synonyms: Irf7^-
• Gene: Irf7 Location: Chr7:140843096-140846412 bp, - strand Genetic Position: Chr7, 86.57 cM, cytoband F5
• Alliance: Irf7^tm1Ttg page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:97662
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A PGK-betageo was inserted to replace exons 2 and 3. Northern and Western blot confirmed ablation of transcript and protein. (J:97662)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Irf7 Mutation: 23 strains or lines available

References

• Original: J:97662 Honda K, et al., IRF-7 is the master regulator of type-I interferon-dependent immune responses. Nature. 2005 Apr 7;434(7034):772-7
• All: 164 reference(s)