Thy1^a
Allele Detail

Summary

• Symbol: Thy1^a
• Name: thymus cell antigen 1, theta; a variant
• MGI ID: MGI:3579311
• Synonyms: theta-AKR, thetaAKR, Thy-1.1, Thy1.1, Thy1a
• Gene: Thy1 Location: Chr9:43954681-43959876 bp, + strand Genetic Position: Chr9, 24.52 cM
• Alliance: Thy1^a page

Mutation origin

• Strain of Origin: Not Applicable

Mutation description

• Allele Type: Not Applicable
• Mutation: Not Applicable
• Mutation details: The allele Thy1^a determines an antigenic specificity, Thy-1.1, found in the AKR and RF strains.

Tumor Data

List all tumor models in MMHCdb carrying Thy1^a

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 39 strains available Cell Lines: 0 lines available
• Carrying any Thy1 Mutation: 211 strains or lines available

Notes

The Thy1 locus determines a surface antigen present on cells of the thymus, a number of mouse leukemias, brain, and in lesser amounts on lymph node and spleen cells. The allele Thy1^a determines an antigenic specificity, Thy-1.1, found in the AKR and RF strains; the allele Thy1^b determines an antigenic specificity, Thy-1.2, found in the C3HeB/Fe and many other strains (J:5243, J:5012, J:4469). The Thy1 antigen is probably present on all T lymphocytes and absent from all B lymphocytes, and it thus serves as a valuable T-cell marker (J:5243). It is very widely used in experiments designed to determine the distribution and function of T-cells. Thy1 specifies a T-cell surface glycoprotein, T25, with a molecular weight of 25 kDa (J:5707). The protein appears to be anchored in the cell membrane by a lipid that is either phosphotidylinositol or closely related to it (J:12016). Thy1 may function in the cell membrane as a signal transduction molecule (J:8333). The Thy1 locus, or possibly a gene closely linked to it, controls quantitative expression of a protein that is the same size as Thy1 and is expressed on thymus and brain but not on lymph node and spleen cells (J:7900).

References

• Original: J:24839 REIF AE, et al., THE AKR THYMIC ANTIGEN AND ITS DISTRIBUTION IN LEUKEMIAS AND NERVOUS TISSUES. J Exp Med. 1964 Sep 1;120:413-33
• All: 107 reference(s)