Eif2ak4^tm1.2Dron
Targeted Allele Detail

Summary

• Symbol: Eif2ak4^tm1.2Dron
• Name: eukaryotic translation initiation factor 2 alpha kinase 4; targeted mutation 1.2, David Ron
• MGI ID: MGI:3582154
• Synonyms: Eif2ak4^tm1Munn, Eif2ak4^tm1Nso, GCN2-KO, GCN2.KO4, GCN2.KO4^ex, GNC2^-
• Gene: Eif2ak4 Location: Chr2:118219099-118305715 bp, + strand Genetic Position: Chr2, 59.4 cM, cytoband E5
• Alliance: Eif2ak4^tm1.2Dron page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:129841
• Parent Cell Line: W4 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Exon 12 was deleted via Cre-mediated excision, removing sequence encoding the essential lysine 618, required for kinase activity. (J:99090)

Expression

In Mice Carrying this Mutation:

104036 assay results 2 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 3 strains available Cell Lines: 0 lines available
• Carrying any Eif2ak4 Mutation: 89 strains or lines available

References

• Original: J:129841 Maurin AC, et al., The GCN2 kinase biases feeding behavior to maintain amino acid homeostasis in omnivores. Cell Metab. 2005 Apr;1(4):273-7
• All: 65 reference(s)