Adgre1^tm1Stst
Targeted Allele Detail

Summary

• Symbol: Adgre1^tm1Stst
• Name: adhesion G protein-coupled receptor E1; targeted mutation 1, Joan Stein-Streilein
• MGI ID: MGI:3582333
• Synonyms: F4/80^-
• Gene: Adgre1 Location: Chr17:57665691-57790527 bp, + strand Genetic Position: Chr17, 29.8 cM
• Alliance: Adgre1^tm1Stst page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:99213
• Parent Cell Line: CJ7 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The coding sequence of exon 1 and the 5' end of intron 1 were replaced by a promoterless beta-galactosidase/pGK-Neo cassette. Northern blot hybridization identified no transcript in mutants. (J:99213)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Adgre1 Mutation: 79 strains or lines available

References

• Original: J:99213 Lin HH, et al., The macrophage F4/80 receptor is required for the induction of antigen-specific efferent regulatory T cells in peripheral tolerance. J Exp Med. 2005 May 16;201(10):1615-25
• All: 5 reference(s)