Fas^tm1Ach
Targeted Allele Detail

Summary

• Symbol: Fas^tm1Ach
• Name: Fas cell surface death receptor; targeted mutation 1, Alexander Chervonsky
• MGI ID: MGI:3589104
• Synonyms: FasKI
• Gene: Fas Location: Chr19:34268066-34305172 bp, + strand Genetic Position: Chr19, 29.48 cM
• Alliance: Fas^tm1Ach page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:123556
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Exon 9 was flanked by loxP sites. A floxed neo was removed via transient cre expression. (J:123556)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Fas Mutation: 82 strains or lines available

References

• Original: J:123556 Stranges PB, et al., Elimination of antigen-presenting cells and autoreactive T cells by Fas contributes to prevention of autoimmunity. Immunity. 2007 May;26(5):629-41
• All: 11 reference(s)