Tecta^tm2Gpr
Targeted Allele Detail

Summary

• Symbol: Tecta^tm2Gpr
• Name: tectorin alpha; targeted mutation 2, Guy P Richardson
• MGI ID: MGI:3605485
• Synonyms: Tecta^Y1870C
• Gene: Tecta Location: Chr9:42240915-42311225 bp, - strand Genetic Position: Chr9, 23.63 cM
• Alliance: Tecta^tm2Gpr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:101691
• Parent Cell Line: CCB (ES Cell)
• Strain of Origin: 129S/SvEv-Gpi1^c

Mutation description

• Allele Type: Targeted (Humanized sequence, Modified isoform(s))
• Mutation: Nucleotide substitutions
• Mutation details: A targeting vector was designed to insert a Y1870C mutation, representing the same mutation found in human partial hearing loss. (J:101691)

Disease models

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 3 strains available Cell Lines: 0 lines available
• Carrying any Tecta Mutation: 133 strains or lines available

References

• Original: J:101691 Legan PK, et al., A deafness mutation isolates a second role for the tectorial membrane in hearing. Nat Neurosci. 2005 Aug;8(8):1035-42
• All: 4 reference(s)