Eif4ebp2^tm1Klan
Targeted Allele Detail

Summary

• Symbol: Eif4ebp2^tm1Klan
• Name: eukaryotic translation initiation factor 4E binding protein 2; targeted mutation 1, Eric Klann
• MGI ID: MGI:3607258
• Synonyms: 4E-BP2 KO
• Gene: Eif4ebp2 Location: Chr10:61268276-61288448 bp, - strand Genetic Position: Chr10, 32.21 cM, cytoband B4-B5
• Alliance: Eif4ebp2^tm1Klan page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:102163
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance cassette replaced exon 2, disrupting amino acids 49-110. Western blot of hippocampal, cortical and cerebellar extracts confirmed the absence of protein in mutants. (J:102163)

Disease models

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Eif4ebp2^tm1Klan

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Eif4ebp2 Mutation: 25 strains or lines available

References

• Original: J:102163 Banko JL, et al., The translation repressor 4E-BP2 is critical for eIF4F complex formation, synaptic plasticity, and memory in the hippocampus. J Neurosci. 2005 Oct 19;25(42):9581-90
• All: 41 reference(s)