Lox^tm1Soin
Targeted Allele Detail

Summary

• Symbol: Lox^tm1Soin
• Name: lysyl oxidase; targeted mutation 1, Raija Soininen
• MGI ID: MGI:3610732
• Synonyms: Lox^-
• Gene: Lox Location: Chr18:52649139-52662939 bp, - strand Genetic Position: Chr18, 28.22 cM
• Alliance: Lox^tm1Soin page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:103389
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Cre mediated recombination was used to excise exon 1, from about 600 bp upstream of the translation start codon to about 90 bp downstream of exon 1. Northern blot confirmed complete inactivation of the gene. (J:103389)

Expression

In Mice Carrying this Mutation:	31 assay results
In Structures Affected by this Mutation:	13 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Lox Mutation: 23 strains or lines available

References

• Original: J:103389 Maki JM, et al., Inactivation of the lysyl oxidase gene Lox leads to aortic aneurysms, cardiovascular dysfunction, and perinatal death in mice. Circulation. 2002 Nov 5;106(19):2503-9
• All: 7 reference(s)