Ccr2^tm1Blck
Targeted Allele Detail

Summary

• Symbol: Ccr2^tm1Blck
• Name: C-C motif chemokine receptor 2; targeted mutation 1, Bruno Luckow
• MGI ID: MGI:3613374
• Synonyms: Ccr2^-, Ccr2^tm1Dscg
• Gene: Ccr2 Location: Chr9:123901987-123913594 bp, + strand Genetic Position: Chr9, 75.05 cM, cytoband F
• Alliance: Ccr2^tm1Blck page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:113343
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

Allele Type: Targeted (Null/knockout, Reporter) Mutations: Insertion, Intragenic deletion Mutation details: Most of the open reading frame is replaced by an EGFP reporter gene and a floxed neomycin resistance cassette. Absence of protein on the cell surface was demonstrated by flow cytometry. (J:113343)

Generation of Ccr2^tm1Blck allele

Disease models

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 3 strains available Cell Lines: 0 lines available
• Carrying any Ccr2 Mutation: 43 strains or lines available

References

• Original: J:113343 de Lema GP, et al., Chemokine receptor Ccr2 deficiency reduces renal disease and prolongs survival in MRL/lpr lupus-prone mice. J Am Soc Nephrol. 2005 Dec;16(12):3592-601
• All: 3 reference(s)