Sufu^tm1Rto
Targeted Allele Detail

Summary

• Symbol: Sufu^tm1Rto
• Name: SUFU negative regulator of hedgehog signaling; targeted mutation 1, Rune Toftgard
• MGI ID: MGI:3619046
• Synonyms: Sufu^-
• Gene: Sufu Location: Chr19:46385335-46477243 bp, + strand Genetic Position: Chr19, 38.85 cM
• Alliance: Sufu^tm1Rto page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:105832
• Parent Cell Line: RW-4 (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A vector was designed to replace part of the promoter, 5' UTR and first exon, including both transcription and translation start sites, with a neomycin resistance cassette. Northern blot did not detect transcript in mutants and Western blot analysis failed to detect protein. (J:105832)

Disease models

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Sufu Mutation: 59 strains or lines available

References

• Original: J:105832 Svard J, et al., Genetic elimination of suppressor of fused reveals an essential repressor function in the mammalian hedgehog signaling pathway. Dev Cell. 2006 Feb;10(2):187-97
• All: 9 reference(s)