Terf2^tm1Tdl
Targeted Allele Detail

Summary

• Symbol: Terf2^tm1Tdl
• Name: telomeric repeat binding factor 2; targeted mutation 1, Titia de Lange
• MGI ID: MGI:3619524
• Synonyms: TRF2^f
• Gene: Terf2 Location: Chr8:107796032-107823179 bp, - strand Genetic Position: Chr8, 53.59 cM
• Alliance: Terf2^tm1Tdl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:105516
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• LoxP sites were inserted to flank exons 1 and 2. (J:105516)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Terf2 Mutation: 31 strains or lines available

Notes

After transient Cre expression, homozygous MEFs display a senescence-like arrest of cell proliferation (J:105516).

References

• Original: J:105516 Celli GB, et al., DNA processing is not required for ATM-mediated telomere damage response after TRF2 deletion. Nat Cell Biol. 2005 Jul;7(7):712-8
• All: 22 reference(s)