Lcn2^tm1Mak
Targeted Allele Detail

Summary

• Symbol: Lcn2^tm1Mak
• Name: lipocalin 2; targeted mutation 1, Tak W Mak
• MGI ID: MGI:3620000
• Synonyms: Lcn2^-
• Gene: Lcn2 Location: Chr2:32274649-32277751 bp, - strand Genetic Position: Chr2, 22.09 cM, cytoband A3
• Alliance: Lcn2^tm1Mak page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:106079
• Parent Cell Line: E14K (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A targeting vector was designed to replace most of the coding region, including exons 1-5, with a neomycin resistance cassette. Western blot failed to detect protein in mutant neutrophils. (J:106079)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Lcn2 Mutation: 29 strains or lines available

References

• Original: J:106079 Berger T, et al., Lipocalin 2-deficient mice exhibit increased sensitivity to Escherichia coli infection but not to ischemia-reperfusion injury. Proc Natl Acad Sci U S A. 2006 Feb 7;103(6):1834-9
• All: 47 reference(s)