Atg5^tm1Myok
Targeted Allele Detail

Summary

• Symbol: Atg5^tm1Myok
• Name: autophagy related 5; targeted mutation 1, Minesuke Yokoyama
• MGI ID: MGI:3663625
• Synonyms: atg5^f, Atg5^flox
• Gene: Atg5 Location: Chr10:44144354-44240287 bp, + strand Genetic Position: Chr10, 23.24 cM
• Alliance: Atg5^tm1Myok page

Cataract development in Atg5^tm1Myok/Atg5^tm1Myok Tg(CAG-EGFP/Map1lc3b)53Nmz/0 Tg(Cryaa-cre)10Mlr/0 mice

Show the 2 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:110050
• Parent Cell Line: CCE/EK.CCE (ES Cell)
• Strain of Origin: 129S/SvEv-Gpi1^c

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A targeting vector was designed to flank exon 3 with loxP sites. A neomycin resistance cassette was included such that expression of cre recombinase would remove both exon 3 and the neo. (J:110050)

Disease models

Expression

In Mice Carrying this Mutation:	2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	20 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Atg5^tm1Myok

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 3 strains available Cell Lines: 0 lines available
• Carrying any Atg5 Mutation: 29 strains or lines available

References

• Original: J:110050 Hara T, et al., Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice. Nature. 2006 Jun 15;441(7095):885-9
• All: 279 reference(s)