Ifih1^tm1.1Cln
Targeted Allele Detail

Summary

• Symbol: Ifih1^tm1.1Cln
• Name: interferon induced with helicase C domain 1; targeted mutation 1.1, Marco Colonna
• MGI ID: MGI:3663677
• Synonyms: Mda-5^-, MDA5^-
• Gene: Ifih1 Location: Chr2:62426142-62476599 bp, - strand Genetic Position: Chr2, 35.85 cM, cytoband C3
• Alliance: Ifih1^tm1.1Cln page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:110201
• Parent Cell Line: SCC10 (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A targeting vector was designed to replace exon 1 and 400 bp of upstream sequence with a floxed MC1-neo cassette. Cre mediated excision removed the MC1-neo, leaving a single loxP site. (J:110201)

Expression

In Mice Carrying this Mutation:

2 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Ifih1 Mutation: 45 strains or lines available

References

• Original: J:110201 Gitlin L, et al., Essential role of mda-5 in type I IFN responses to polyriboinosinic:polyribocytidylic acid and encephalomyocarditis picornavirus. Proc Natl Acad Sci U S A. 2006 May 30;103(22):8459-64
• All: 70 reference(s)