Tbx1^tm5Bld
Targeted Allele Detail

Summary

• Symbol: Tbx1^tm5Bld
• Name: T-box 1; targeted mutation 5, Antonio Baldini
• MGI ID: MGI:3664784
• Synonyms: Tbx1^neo2
• Gene: Tbx1 Location: Chr16:18399729-18409412 bp, - strand Genetic Position: Chr16, Syntenic
• Alliance: Tbx1^tm5Bld page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:112457
• Parent Cell Line: AB2.2 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1^b-m2

Mutation description

• Allele Type: Targeted (Conditional ready, Hypomorph)
• Mutation: Insertion
• Mutation details: A floxed neo was inserted into intron 5. This is a hypomorphic allele that can revert to a functional allele upon Cre recombination. (J:112457)

Expression

In Mice Carrying this Mutation:	36 assay results 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	15 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Tbx1 Mutation: 36 strains or lines available

References

• Original: J:112457 Zhang Z, et al., Mesodermal expression of Tbx1 is necessary and sufficient for pharyngeal arch and cardiac outflow tract development. Development. 2006 Sep;133(18):3587-95
• All: 7 reference(s)