Ace2^tm1Cof
Targeted Allele Detail

Summary

• Symbol: Ace2^tm1Cof
• Name: angiotensin converting enzyme 2; targeted mutation 1, Thomas M Coffman
• MGI ID: MGI:3665270
• Gene: Ace2 Location: ChrX:162922338-162971414 bp, + strand Genetic Position: ChrX, 76.12 cM, cytoband F5
• Alliance: Ace2^tm1Cof page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:113108
• Parent Cell Line: MPI-12D (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin selection cassette replaced an exon containing sequences encoding the zinc-binding motif HEMGH. Northern blot analysis of RNA derived from kidney of mutant mice revealed that no detectable transcript is expressed from this allele. (J:113108)

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ace2 Mutation: 66 strains or lines available

References

• Original: J:113108 Gurley SB, et al., Altered blood pressure responses and normal cardiac phenotype in ACE2-null mice. J Clin Invest. 2006 Aug;116(8):2218-25
• All: 33 reference(s)