Cd79a^tm1(cre)Reth
Targeted Allele Detail

Summary

• Symbol: Cd79a^tm1(cre)Reth
• Name: CD79A antigen (immunoglobulin-associated alpha); targeted mutation 1, Michael Reth
• MGI ID: MGI:3687451
• Synonyms: Cd79a^-, Cd79a-Cre, mb1-cre, mb.1-Cre, mb1^Cre, Mb-1Cre
• Gene: Cd79a Location: Chr7:24596922-24601283 bp, + strand Genetic Position: Chr7, 13.49 cM
• Alliance: Cd79a^tm1(cre)Reth page

Small spleen size in Atmin^tm1.2Jhh/Atmin^tm1.2Jhh/ Cd79a^tm1(cre)Reth/Cd79a⁺ mice

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:113645
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: BALB/c

Mutation description

• Allele Type: Targeted (Null/knockout, Recombinase)
• Mutation: Insertion
• Cd79a^tm1(cre)Reth expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Cd79a (MGI:101774)

• Mutation details: Exons 2 and 3 of the Cd79a gene were replaced with a cDNA encoding a mammalian codon-optimized cre (hCre) followed by an SV40 poly(A) signal. Exon 1 was truncated to remove the Cd79a ATG start codon, and a tk-neo cassette flanked by FRT sites was introduced 3' to hCre. The neo cassette was deleted in chimeras by crossing to Flpe deleter mice. (J:113645, J:135783)

Generation of the floxed Atmin^tm1.2Jhh allele

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Cd79a (mouse) Summary of all recombinase alleles driven by Cd79a. Alliance mouse Cd79a gene page

Disease models

Expression

In Mice Carrying this Mutation:

10 RNA-Seq or microarray experiment(s)

Tumor Data

List all tumor models in MMHCdb carrying Cd79a^tm1(cre)Reth

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 3 strains available Cell Lines: 0 lines available
• Carrying any Cd79a Mutation: 24 strains or lines available

References

• Original: J:113645 Hobeika E, et al., Testing gene function early in the B cell lineage in mb1-cre mice. Proc Natl Acad Sci U S A. 2006 Sep 12;103(37):13789-94
• All: 351 reference(s)