Tlr3^tm1Aki
Targeted Allele Detail

Summary

• Symbol: Tlr3^tm1Aki
• Name: toll-like receptor 3; targeted mutation 1, Shizuo Akira
• MGI ID: MGI:3690535
• Synonyms: Tlr3^-, Tlr3^tm1Ttg
• Gene: Tlr3 Location: Chr8:45848702-45864112 bp, - strand Genetic Position: Chr8, 25.31 cM, cytoband B2
• Alliance: Tlr3^tm1Aki page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:114555
• Parent Cell Line: E14.1TG3B1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• The third and fourth exons of the coding region were replaced with a neomycin resistance cassette. (J:114555)

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Tlr3 Mutation: 68 strains or lines available

References

• Original: J:114555 Honda K, et al., Selective contribution of IFN-alpha/beta signaling to the maturation of dendritic cells induced by double-stranded RNA or viral infection. Proc Natl Acad Sci U S A. 2003 Sep 16;100(19):10872-7
• All: 77 reference(s)