Ptf1a^tm2.1Mgn
Targeted Allele Detail

Summary

• Symbol: Ptf1a^tm2.1Mgn
• Name: pancreas specific transcription factor, 1a; targeted mutation 2.1, Mark A Magnuson
• MGI ID: MGI:3691484
• Synonyms: Ptf1a^Citrine, Ptf1a^tm2Mgn, Ptf1a^YFP
• Gene: Ptf1a Location: Chr2:19450474-19452312 bp, + strand Genetic Position: Chr2, 13.37 cM, cytoband A2
• Alliance: Ptf1a^tm2.1Mgn page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:115271
• Parent Cell Line: TL1/TL-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted
• Mutation: Insertion
• Mutation details: This allele expresses citrine under the control of the endogenous promoter. Exons 1 and 2 were replaced by the citrine yellow variant of GFP inserted into exon 1, exon 2 and an frt-flanked hygro cassette via RMCE using the loxed cassette acceptor (LCA) allele-containing ES cells. (J:115271, J:135698)

Expression

In Mice Carrying this Mutation:

163 assay results 2 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ptf1a Mutation: 31 strains or lines available

References

• Original: J:115271 Fujitani Y, et al., Ptf1a determines horizontal and amacrine cell fates during mouse retinal development. Development. 2006 Nov;133(22):4439-50
• All: 6 reference(s)