Foxp3^{tm3(HBEGF/GFP)Ayr}
Targeted Allele Detail

Summary

• Symbol: Foxp3^{tm3(HBEGF/GFP)Ayr}
• Name: forkhead box P3; targeted mutation 3, Alexander Y Rudensky
• MGI ID: MGI:3698131
• Synonyms: Foxp3-DTR, Foxp3^DTR, Foxp3-GFP, Foxp3-IRES-DTR-GFP KI (FDG), Foxp3^tm3Ayr, Foxp3^{tm3(DTR/GFP)Ayr}
• Gene: Foxp3 Location: ChrX:7445915-7461482 bp, + strand Genetic Position: ChrX, 3.41 cM
• Alliance: Foxp3^{tm3(HBEGF/GFP)Ayr} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:117743
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Inserted expressed sequence, Reporter)
• Mutation: Insertion
• Foxp3^{tm3(HBEGF/GFP)Ayr} expresses 1 gene
  Knock-in expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  HBEGF (1839)

  Hbegf

  (MGI:96070)

• Mutation details: A targeting vector was designed to insert a cDNA encoding the human diphtheria toxin receptor (HBEGF/DTR) fused to sequences encoding a green fluorescent protein (GFP) equipped with an internal ribosome entery (IRES), IRES-DTR-GFP with a floxed neo into the 3' untranslated region downstream of exon 11 of the Foxp3 gene. (J:117743)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Foxp3 Mutation: 58 strains or lines available

References

• Original: J:117743 Kim JM, et al., Regulatory T cells prevent catastrophic autoimmunity throughout the lifespan of mice. Nat Immunol. 2007 Feb;8(2):191-7
• All: 220 reference(s)