Pde8a^tm1Dgen
Targeted Allele Detail

Summary

• Symbol: Pde8a^tm1Dgen
• Name: phosphodiesterase 8A; targeted mutation 1, Deltagen
• MGI ID: MGI:3699271
• Gene: Pde8a Location: Chr7:80863344-80984281 bp, + strand Genetic Position: Chr7, 45.71 cM
• Alliance: Pde8a^tm1Dgen page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:118251
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd
• Project Collection: Deltagen

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A lacZ-neomycin resistance cassette replaced 38 nucleotides of the gene disrupting part of exon 17, which normally encodes the third helix of the catalytic domain. Immunoprecipitation failed to detect activity in mutant mice. (J:118251)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Pde8a Mutation: 55 strains or lines available

References

• Original: J:118251 Vasta V, et al., Modulation of Leydig cell function by cyclic nucleotide phosphodiesterase 8A. Proc Natl Acad Sci U S A. 2006 Dec 26;103(52):19925-30
• All: 4 reference(s)