Tg(MSR1-Pon1)1Road
Transgene Detail

Summary

• Symbol: Tg(MSR1-Pon1)1Road
• Name: transgene insertion 1, Roger A Davis
• MGI ID: MGI:3699359
• Synonyms: PON1-Tg
• Transgene: Tg(MSR1-Pon1)1Road Location: unknown
• Alliance: Tg(MSR1-Pon1)1Road page

Transgene origin

• Strain of Origin: C57BL/6J

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(MSR1-Pon1)1Road expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Pon1 (MGI:103295)

• Mutation details: The coding region of mouse PON1 was placed under the control of the macrophage-specific human scavenger receptor A (MSR1) gene regulatory elements and the human growth hormone polyadenylation signal. Analysis of mRNA from transgenic mice showed that the construct was expressed only in circulating monocyte/macrophages and tissues containing resident macrophages (i.e., liver, lung, spleen, but not in heart, kidney, brain, or skeletal muscle). (J:118732)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:118732 Bradshaw G, et al., Facilitated replacement of Kupffer cells expressing a paraoxonase-1 transgene is essential for ameliorating atherosclerosis in mice. Proc Natl Acad Sci U S A. 2005 Aug 2;102(31):11029-34
• All: 1 reference(s)